Biomarkers of Language Processing in Children with Neurodevelopmental Disorders
What is the LISTEN Study about?
Most individuals with Angelman syndrome (AS) are non-verbal and approximately 30% of individuals with autism spectrum disorder (ASD) remain minimally or non-verbal into adulthood. Using behavioral and brain-based (EEG) measures in this study, we intend to develop assessment tools and identify biomarkers that do not rely on a child’s ability to understand directions or produce an intentional response.
Who can participate?
We are actively enrolling children 5-11 years old with a genetic diagnosis of AS, ASD diagnosis, as well as typically developing children.
What does the study involve?
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- This study includes 1 timepoint for ASD and TD participants and 2 timepoints for AS participants
- Timepoints can be split into 2 visits if the family prefers
- Electroencephalogram (EEG)
- EEG is a way for us to study the dynamics of neural networks and measure electrical activity in brains. The EEG will take approximately 15 minutes. Your child will wear a mesh cap with small, non-invasive sensors that measure brain signals while videos and sounds are played, and images are shown.
Behavioral Assessments
Cognition and development of participants will be assessed at their first visit. These measures will be administered by a trained clinical psychologist.
Help Us
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- Learn more about language processing in ASD and AS
- Develop tools and identify biomarkers for language development in ASD
- Identify biomarkers and develop tools for use in AS clinical trials
Compensation
You will receive compensation for your time and effort for each visit.